Elucidating the Skin Delivery of Aglycone and Glycoside Flavonoids: How the Structures Affect Cutaneous Absorption
نویسندگان
چکیده
Flavonoids are bioactive phytochemicals that exhibit protective potential against cutaneous inflammation and photoaging. We selected eight flavonoid aglycones or glycosides to elucidate the chemistry behind their skin absorption capability through experimental and computational approaches. The skin delivery was conducted using nude mouse and pig skins mounted on an in vitro Franz cell assembly. The anti-inflammatory activity was examined using the O₂•.
منابع مشابه
Penetration and Metabolism of Isoflavones in Human Skin
This human study shows that the isoflavone aglycone genistein penetrates significantly better into the skin when it is formulated in a liposomal preparation. The corresponding isoflavone glycoside genistin is not hydrolyzed to the biologically active aglycones upon topical application. Daniel Schmid and Fred Zülli Mibelle AG Cosmetics, Buchs, Switzerland Hans-Peter Nissen and Hanspeter Prieur D...
متن کاملFabrication of polymeric microneedle arrays containing Amphotericin-B for transdermal drug delivery
Background and Aim: Drug delivery through the microneedle array has been considered as an easy and non-invasive method in recent years. The purpose of this study was to design and construct an array of biodegradable polymeric microneedles containing Amphotericin-B to introduce this system and its use in the treatment of cutaneous lesions caused by Leishmania major parasite inoculation as a mode...
متن کاملMeloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation
Objective(s):Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a m...
متن کاملPharmacokinetic Study of Bioactive Flavonoids in the Traditional Japanese Medicine Keigairengyoto Exerting Antibacterial Effects against Staphylococcus aureus
Recent studies have demonstrated that flavonoid glucuronides can be deconjugated to the active form aglycone by β-glucuronidase-expressing macrophages. Keigairengyoto (KRT) is a flavonoid-rich traditional Japanese medicine reported to enhance bacterial clearance through immune modulation. Our aims are to examine the pharmacokinetics of KRT flavonoids and to identify active flavonoids contributi...
متن کاملA validated HPLC determination of the flavone aglycone diosmetin in human plasma.
Diosmetin, 3',5,7-trihydroxy-4'-methoxy flavone, is the aglycone of the flavonoid glycoside diosmin that occurs naturally in foods of plant origin. Diosmin exhibits antioxidant and anti-inflammatory activities, improves venous tone and it is used for the treatment of chronic venous insufficiency. Diosmin is hydrolyzed by enzymes of intestinal micro flora before absorption of its aglycone diosme...
متن کامل